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Mechanics of bone and bone-implant systems

Musculoskeletal disorders are among the most disabling and costly health conditions. Given the aging population, health care costs are expected to double in just a few years time. With our research we aim to improve the diagnosis of bone-related pathologies and their treatment, and includes an improved quantification of treatment effects. A major focus is on the effects of osteoporosis. Osteoporosis is a skeletal disease resulting in reduced bone strength and increased fracture risk. Given the intricate structure and composition of bone, this work requires the integration of structural and material properties from different length scales, from the skeleton, through bones and bone tissue to the cell. At KU Leuven and ETH Zurich we are using state-of-the-art imaging techniques, in combination with computer simulations and experimental testing to quantify the mechanics of bone and bone-implant systems


Key words: bone mechanical properties, bone adaptation, bone modeling and remodeling, orthopaedic implants, implant fixation, hierarchical imaging, finite element analysis, bone mechanical loading, computed tomography, CT, CBCT, micro-CT, human, rat, mouse.